This category refers to the original and ongoing "Two Best Friends Play", later re-named to "New Super Best Friends Play", series featured on Machinima. These episodes are heavily edited Let's Plays of Matt and Pat. Most often, they are recently released titles.
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- Saints Row IV
- Saints Row The Third
- Saints Row: Gat Out of Hell
- Scribblenauts Wii U
- Shadow of Mordor
- Shadows of the Damned
- Sherlock Holmes: The Devil's Daughter
- Silent Hill: Shattered Memories
- Skyrim
- Skyrim: Special Edition
- Sleeping Dogs
- Slender
- Slender: The Arrival
- Soul Calibur V
- Spider-Man Games
- Star Trek
- Star Wars Battlefront
- Steel Battalion: Heavy Armor
- Street Fighter III 3rd Strike Online Edition
- Super Mario 3D World
- Super Nintendo
- Superman Returns
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